To understand the pharmacokinetic mechanisms of Gd-EOB-DTPA and the MR imaging sequences that use this contrast agent
To underline the typical and atypical appearances of hepatocellular carcinoma (HCC)
More than half a million people worldwide,
with 20000 new cases in the United States,
are diagnosed with hepatocellular carcinoma,
Liver cancer is the fifth common cancer in men and seventh in women and the highest incidence is in regions where the infection with hepatitis B virus (HBV) is endemic: South Africa and Southeast Asia.
The major risk factors for HCC are: HBV or HCV,
alcoholic liver disease,
nonalcoholic fatty liver disease,
Findings and procedure details
The recommended dose of Gd-EOB-DTPA is: 0.025mmoli/kg,
at a flow rate of about 2 mL/sec (only 25% of the Gd-DTPA standard preparation) .
The contrast medium volume is relatively small,
and the use of 20-30ml of saline flush after contrast agent injection is more than necessary,
in order to optimize the arterial phase.
Also the imaging acquisition requires coordination after administration,
which can be done by using,
either bolus timing techniques (such as...
Understanding the new insights into MR liver imaging is essential for an accomplished diagnosis, Gd-EOB-DTPA-enhanced sequences offering a major achievement in the detection and characterization of HCCs.
Global cancer statistics.
CA Cancer J Clin.
3. Van Beers BE, Pastor CM, Hussain HK.
Eovist: What to expect?.
J Hepatol. 2012 Aug;57(2):421-9.
4. Semelka RC, Helmberger TK.
Contrast agents for MR imaging of the liver.
Radiology. 2001 Jan;218(1):27-38....