Aims and objectives
Mammographic breast density is an independent risk factor for breast cancer and is also associated with numerous known breast cancer risk factors such as reproductive history and hormone replacement therapy.[1-4] Numerous studies have shown that women with high breast density have an increased risk of breast cancer compared to those with predominantly fatty breasts.[3,
mammographic density reduces the sensitivity of mammography to detect breast cancer.
Methods and materials
Study Design and Sample
A case-control study was performed using full field digital mammography images from 424 women with unilateral screen-detected breast cancer and 848 age-matched screening controls.
All subjects were women who had a digital screening examination taken through the Nova Scotia Breast Screening Program (NSBSP) between January 1,
2009 and June 30,
2011 and who were aged 40 to 75 at time of screening.
The NSBSP is responsible for oversight of the delivery of all...
89 individual observations (7%) were excluded because of missing data,
leaving a total of 374 cases and 809 controls for analysis.
Characteristics of case and control subjects are summarized in Table 1.
The mean age at screen for both cases and controls was 58.9 years.
Cases and controls were similar with respect to parity,
hormone replacement therapy use,
menopausal status and family history.
Adjusted ORs and 95% confidence intervals describing the odds of breast...
The results of this study indicate that women with extremely dense breasts as defined by the BI-RADS density lexicon (5th edition) have five times higher odds of screen-detected breast cancer relative to those with almost entirely fatty breasts.
The odds ratios observed in this study for women in the highest density group versus those in the lowest density risk group are consistent with those previously observed when measures of percent density have been used to stratify women into...
Contact Author: Mohamed Abdolell,
Department of Diagnostic Radiology,
Duffy SW (2012) Clinical and Epidemiological Issues in Mammographic Density.
(2005) Mammographic breast density as an intermediate phenotype for breast cancer.
Lancet Oncology 6:798–808.
Bovbjerg VE (2004) Quantitative Assessment of Mammographic Breast Density: Relationship with Breast Cancer Risk.