Aims and objectives
To compare the efficacy of orally-administered manganese chloride tetrahydrate CMC 001 and Gd-chelate-enhanced MR images for the evaluation of focal liver lesions.
MRI is an important modality for the detection and characterization of focal liver lesions (FLL),
whether primary tumors,
such as hepatocellular carcinoma,
or secondary tumors,
such as metastases. Although an unenhanced MR of the liver is superior to an unenhanced CT for this purpose,...
Methods and materials
Methods and Materials:Subjects:
The study consisted of a total of 49 subjects with liver metastases,
including 23 men (47%) and 26 women (53%),
with a mean age of 48 years (range 17-83 years). The study population included 27 patients from four Phase II or III clinical trials (26 patients with liver metastases and one healthy subject),
as well as 22 patients with liver metastases who were studied as part of a compassionate use program.
Image Quality Assessment:
the image quality on pre-contrast plus CMC 001-enhanced MR images demonstrated optimal quality in 86% compared to 67% in Gd-enhanced MRI. This difference was statistically significant (p<0.0001)(Table 4). A breakdown of the various artifacts reveals that
respiratory motion was the main artifact encountered with unenhanced plus CMC 001-enhanced MRI,
while cardiovascular motion was the main artifact encountered with Gd-enhanced MRI...
This initial analysis with orally-administered manganese chloride tetrahydrate (CMC 001) demonstrates that when combined with pre-contrast images,
there is similar image quality,
as well as confidence in lesion detection and delineation compared to Gd-enhanced images.
Post-contrast T1-weighted imaging with 1600 mg demonstrates significant enhancement of the liver parenchymal and CBD.
MR signal changes on hepatobiliary imaging after oral ingestion of manganese chloride tetrahydrate: preliminary examination.
Jpn J Radiol.
A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and phamaceutical aspects. Acta Radiol.
Manganese chloride tetrahydrate...