Aims and objectives
Density is a recognized risk factor for breast cancer (1). This study aims to map density variation across a screening population and to identify demographic distinctions which may affect density and impact cancer development/detection.
we focus on impact of age on density,
ethnicity on density,
and deprivation index on density.
Methods and materials
This retrospective study on a screening population adheres to local patient confidentiality requirements. Breast density data was obtained from screening mammograms obtained from March 2013-September 2014. All mammograms were performed on Hologic Selenia and Dimensions machines (2011).
At the time of the study, the United Kingdom,
standard screening age was 50-70.
After age 70,
women must self-refer to undergo screening....
32,685 screening records were evaluated (age range 41-90).
Figure 2 shows the distribution of the ages in the study according to prevalent versus incident screen.
The distribution reflects the parameters of the Southwest London United Kingdom screening program; during the time period of the study,
women ages 49-70 were invited for screening.
(Women younger than 49 are most likely to be high risk and therefore enrolled in special screening...
Breast density is a known risk factor for breast cancer (1,6,7).
A variety of studies have suggested that certain demographic factors may be predictive of breast density and,
of breast cancer risk (8-12).
Our study focuses on teasing out the relationship between density and demographic characteristics which are readily obtainable through our screening program records,
and socioeconomic status/deprivation index....
The authors would like to acknowledge VolparaSolutions and Philips for their support.
1. Boyd NF,
Martin LJ et al.
Mammographic density and the risk and detection of breast cancer. N Engl J Med.
Shepherd J et al.
Digital mammographic density and breast cancer risk: a case inverted question markcontrol study of six alternative density assessment methods. Breast Cancer Res.
3. R Core Team.
R: A language and environment for statistical computing.
R Foundation for Statistical Computing,