Degenerative changes in Alzheimer's Disease (AD) show mainly in grey matter and first appear in entorhinal cortex,
and posterior cingulate cortex,
then progressing through entire cerebral cortex [Braak].
Abnormalities in white matter are not immediately visible in standard MRI imaging,
proven by histopathological testing .
Mild cognitive impairment (MCI) is a set of clinical symptoms described...
Methods and Materials
The participants in this study were 60 patients aged between 50 and 80 years (mean age 64 +/-9[SD]).
Patients were divided into 3 groups (Table 1).
Table 1: Study group
Early stage of AD
Number of patients
*Mean+/-standard deviation **Range
The research included patients between the ages of 50 and 80 meeting the criteria...
A preliminary analysis of the volumetric values of normalised average volumes of individual structures revealed the expected decrease/increase in partial volumes when groups of patients were compared (Table 2).
1 shows the plot of normed mean volumes.
Obtained volumetric data was checked for any linear correlation between ages of individual patients within groups,
and did not show any significant relationship.
Similar results were received in the correlative analysis of ages and...
Hippocampal volumes decrease among tested groups of patients as the illness progresses,
which is particularly apparent when we compare patients suffering from cognitive impairments (MCI as well as AD) with the ones in the control group.
Such evident differences were not observed between the MCI and AD groups,
presumably because of high heterogeneity among the MCI group (different variations: amnesic,
Volumes of individual parts of the ventricular system increased as...
 Rozpoznawanie i leczenie otępień,
 Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water
Yue Cheng Xu,
Cortical surface-based analysis.
Segmentation and surface reconstruction.
Improved localization of...