Mammographic breast density describes the proportion of radiopaque,
fibroglandular tissue in the breast.
Higher breast densities are strongly associated with an increased risk of breast cancer,
with women reported to have a four- to six-fold increase in breast cancer risk if they have extremely dense breasts,
compared to women with predominantly fatty breasts [1-3].
Higher densities are also correlated with a decrease in the sensitivity of mammographic screening,
due to the potential masking...
Methods and Materials
Mammographic images The “For Processing” and “For Presentation” mammographic images were obtained for 12 cases from a US site.
Craniocaudal (CC) and medio-lateral oblique (MLO) mammographic views were taken of each breast,
for each case.
Each woman had given their prior consent to their mammograms being used for research purposes. BI-RADS assessment by radiologists An experienced radiologist from South Korea,
the Netherlands and the US,
reviewed the “For Presentation” mammograms...
Country-to-country variability by BI-RADS categories The average BI-RADS scores (over the 12 cases; see Table 1) by the South Korean and Netherlands radiologists were 2.33 and 2.17,
The average BI-RADS score,
determined by both the US radiologist and Volpara™,
Compared to the South Korean radiologist,
the US radiologist assigned a higher BI-RADS density score in five out of the 12 cases,
and a lower BI-RADS score in only one case.
Volpara™ gave a higher...
The fact that the average BI-RADS score for both Volpara™ and the US radiologist was the same (2.67) is not unexpected,
as Volpara™ was set based on a US radiologist’s assessment of BI-RADS density.
The highest level of agreement was between the South Korean and Netherlands radiologists (83%).
it should be noted that when there were discrepancies between the US radiologist’s scores compared to the other radiologists’ BI-RADS readings,
both the South Korean and Netherlands...
Mammographic density and the risk of detection of breast cancer.
New Engl J Med 2007; 356:227-36. Mandelson MT,
Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers.
J Natl Cancer Inst 2000; 92:1081-7. McCormack VA and dos Santos S.
Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis.
Cancer Epidemiol Biomarkers Prev 2006;...
Matakina Technology Ltd,
New Zealand; firstname.lastname@example.org Ariane Chan PhD,
New Zealand; email@example.com Ralph Highnam PhD,
New Zealand; firstname.lastname@example.org