Cortical thickness mapping is a computational analysis technique that uses clinical computed tomography (CT) imaging to plot the distribution of cortical bone thickness in 3D (Treece et al.,
2010 and 2012).
It is able to accurately estimate cortical thickness from clinical CT imaging data down to 0.3mm,
far better than the inherent resolution of the CT imaging system.
Given the understanding of the relationships of age, weight,
and osteophytes with bone...
Methods and Materials
We analysed CT imaging data from a cohort of 230 women aged 66±17 years,
selecting one hip from each randomly according to side.
Demographics for these participants are shown in table 1.
A DICOM analysis tool (Stradwin: http://mi.eng.cam.ac.uk/~rwp/stradwin/) was used to contour each hip semi-automatically and create a 3D surface mapped with individual cortical thickness values according to a colour scale (figure 1).
Stages of the cortical thickness mapping process...
Mean cortical thickness maps generated from the 230 selected hips are shown in figure 3.
Cortical thickness was generally thinner with advancing age,
but was preserved in characteristic load-bearing regions at the medial femoral neck and lateral subtrochanteric cortex (figures 4a and 4b).
Greater weight was also associated with significantly thicker cortex per kilogram at the same sites (figures 4c and 4d).
Increasing osteophyte severity (as determined by...
The finding of generalised thinner cortical bone with advancing age supports the established notion that bone mineral density reduces throughout life after early adulthood (Looker et al.,
We also show a region of age-preserved and weight-thickened cortical bone that co-localises with peak compressive stress in the mid-gait cycle (Wagner et al.,
suggesting that cortex here may be responding to ground reaction forces.
Although the relationship between...
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At the time of this work,
Tom Turmezei was the 2011 Evelyn Trust Research Fellow with the Bone Research Group in the Department of Medicine at the University of Cambridge,
UK. He has completed clinical radiology training with musculoskeletal specialisation and is now studying for a PhD in Cambridge.
Graham Treece is the Evelyn Trust Lecturer in Engineering for Clinical Practice in the Department of Engineering at the University of Cambridge.
Andrew Gee is a Reader...